在美国的西班牙裔/拉丁裔中,肠道微生物群,血液代谢物和左心室透静功能障碍
Kai Luo1, Alkis Taryn2, Eun-Hye Moon2
1Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Microbiome
|May 9, 2024
概括
肠道细菌及其代谢物与左心室透静功能障碍 (LVDD) 有关,这是心力衰竭的前体. 识别这些微生物特征可能会改善LVDD预测和预防策略.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 心血管疾病流行病学
背景情况:
- 左心室扩张性功能障碍 (LVDD) 在心力衰竭 (HF) 之前,但其肠道微生物组的联系尚不清楚.
- 西班牙裔/拉丁裔人口的LVDD负担很高,使他们非常适合这项研究.
- 肠道失调和微生物代谢物可能在LVDD发展中发挥作用.
研究的目的:
- 描述与LVDD相关的肠道微生物群.
- 为了识别肠道失调和事件LVDD的代谢物标志.
- 探索这些信号对LVDD的预测价值.
主要方法:
- 利用了来自西班牙裔社区健康研究/拉丁裔研究 (HCHS/SOL) 的多学科数据.
- 微生物组组合分析 (ANCOM-II) 用于识别与LVDD相关的细菌.
- 使用多变量回归来将细菌,代谢物和LVDD发病率联系起来.
主要成果:
- 鉴定了7种与流行的LVDD相关的主导肠道细菌物种.
- 将220种循环代谢物与LVDD相关的细菌联系在一起,其中46种与流行LVDD相关.
- 21种与细菌相关的代谢物改善了发生LVDD的预测 (AUC为0.73对0.70).
结论:
- 多种肠道细菌及其代谢物与美国西班牙裔/拉丁裔的LVDD有关.
- 这些发现表明肠道微生物产品在临床前心力衰竭中的潜在作用.
- 代谢物签名显示了改善LVDD预测的前景.
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