在年轻的非致残性脑内出血患者中异常的动态功能连接
Dan Yang1, Xiangqi Luo2, Shengjun Sun3
1Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Annals of clinical and translational neurology
|May 10, 2024
概括
脑内出血患者表现出改变的动态功能网络连接,与认知缺陷相关的状态过渡较少. 大脑网络动态的这些变化可能是中风后神经认知障碍的基础.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 认知科学 认知科学
背景情况:
- 休息状态功能磁共振成像 (fMRI) 研究往往忽视了脑内出血 (ICH) 中的动态大脑活动.
- 了解时间变化的功能连接对于阐明ICH的神经认知影响至关重要.
研究的目的:
- 研究ICH患者的动态功能网络连接 (dFNC) 改变.
- 探索dFNC异常与认知表现之间的关系.
主要方法:
- 利用37名ICH患者和44名对照患者的fMRI数据的独立组件分析,滑动窗口和k-means集群.
- 分析了dFNC状态和时间性质的组间差异.
- 与已识别的功能连接性指数相关联的临床规模得分.
主要成果:
- 确定了10个静态网络,并将dFNC集成到四个状态中.
- 与对照组相比,ICH患者的状态过渡数量减少,与Trail Making Test得分相关.
- 在状态1期间,ICH患者观察到小脑和执行控制网络的连接性减少,这与动物流利性测试的表现有关.
结论:
- ICH患者表现出明显的dFNC特征,包括改变的时间动态.
- 异常的功能连接模式和时间性质与中风后的认知领域表现相关.
- 这些发现为ICH背后的神经认知机制提供了新的见解.
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