在人类胰腺癌中,与炎症相关的细胞内脂质变化导致胰腺癌缓解症
Min Deng1, Jianhua Cao2, Gregory van der Kroft1,3
1Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Journal of cachexia, sarcopenia and muscle
|May 10, 2024
概括
癌症缓解症涉及骨肌肉损失和炎症. 这项研究发现,卡塞克症患者的细胞内脂质积累在类型和分布上有所不同,与炎症标志物相关.
科学领域:
- 在瘤学瘤学.
- 代谢综合征是代谢综合征的一种.
- 利皮多米克 (Lipidomics) 是一种消化剂.
背景情况:
- 癌症缓解症是一种具有炎症和肌肉损失的代谢综合征,影响患者的生存和生活质量.
- 骨肌中的脂质积累与癌症缓解症和预后有关,但具体的脂质类型及其与炎症的关系尚不清楚.
研究的目的:
- 在患有癌症和没有癌症的患者中确定细胞内脂质的类型和分布.
- 为了研究细胞内脂质积累和癌症缓解症中的炎症之间的关系.
主要方法:
- 来自胰腺癌患者的直腹肌活检的分析 (有/没有炎症的卡赫西克和非卡赫西克).
- 通过CT扫描来评估身体组成,并使用Oil-Red O和H&E染色来评估肌肉脂质含量/缩.
- 通过LC-MS/MS和质谱成像对神经管的非向性脂质组分析; qPCR用于炎症标志物和胺合成基因.
主要成果:
- 与没有炎症的非卡赫西克或卡赫西克患者相比,有炎症的卡赫西克患者显示较低的肌肉辐射衰减和更高的细胞内脂质含量.
- 内肌细胞脂质积累与局部IL-6和全身CRP水平相关.
- 缓解症患者表现出糖脂和糖脂的相对丰度变化,特定的脂类物种 (例如,SM(d36:1),PC(34:1),TG(48:1)) 在炎症患者中增加,并显示空间分布不均.
结论:
- 癌症缓解症中的细胞内脂质积累与局部和全身炎症有关.
- 卡塞克斯肌肉中的脂质概况以特定脂质物种的变化为特征,包括甘油脂和甘油脂脂.
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