在多发性硬化症中,内在和外在的贡献者导致了亚区域性乳头体积损失
Eva A Krijnen1,2, Elsa Salim Karam1, Andrew W Russo1
1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Annals of clinical and translational neurology
|May 10, 2024
概括
多发性硬化症通过内部细胞变化和外部白质损伤引起乳头缩. 这些微观结构因素在各种thalamic亚区域中对体积损失的贡献不同.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
背景情况:
- 多发性硬化症 (MS) 是一种影响中枢神经系统的慢性炎症性疾病.
- 甲状腺缩是MS患者残疾的一个重要因素.
- 了解胸膜缩的微观结构基础对于开发向疗法至关重要.
研究的目的:
- 调查 MS 中特定的胸膜子区域中导致缩的内在和外在微观结构因素.
- 利用先进的体内高梯度扩散MRI技术进行详细的微观结构分析.
主要方法:
- 在41名多发性硬化患者和34名健康对照组中进行了横截面研究.
- 使用高梯度扩散成像 (300 mT/m) 和多协议的3T MRI.
- 用索马和神经元密度成像 (SNDI) 模型进行体积和扩散度分析,将thalamic分为25个子区域.
主要成果:
- 与MS相关的体积损失在后部/中部乳头下部区域更为严重.
- 在MS中观察到细胞体内信号分数 (细胞体密度) 的减少和细胞外信号分数 (细胞外空间) 的增加,特别是在后部/中部区域.
- 白质中的较低的神经细胞内信号分数和连接皮层中的较低的神经细胞内信号分数与减少的乳头体积相关.
结论:
- 内在的 (神经元/体质密度) 和外在的 (白质/皮质完整性) 微观结构因素都独立地导致MS的乳头亚区域缩.
- 这些发现表明前进退行退行退化的结合,可能是由于白质脱髓化和脑脊液介导的损伤.
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