多重瘤病毒病症:诊断,组织学特征,以及与急性排斥的区别
1Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Clinical transplantation and research
|May 10, 2024
概括
由于BK病毒的重新激活,多瘤病毒病 (PVN) 可能在移植后发生. 组织学分类有助于诊断,预后,并区分PVN与排斥.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 病毒学 病毒学
- 移植免疫学 移植免疫学
背景情况:
- 多种病毒,特别是BK病毒,建立潜伏感染,在移植接受者的免疫抑制下重新激活.
- 再激活可以导致多病毒脏病 (PVN),这是移植功能障碍和损失的重要原因.
研究的目的:
- 审查PVN的诊断方法,包括查和最终诊断.
- 讨论PVN的组织学分类及其与临床结果的相关性.
- 要突出区分PVN与急性细胞介导排斥的挑战.
主要方法:
- 诊断工具的审查:用于查和推定诊断的病毒尿和病毒血水平.
- 脏活检用于确定PVN诊断.
- 基于病毒载量,纤维化和炎症的组织学分类的分析.
主要成果:
- PVN的组织学分类与移植功能,损失,治疗疗效和预后相关.
- 提示性组织学特征可以帮助区分PVN与急性排斥,尽管发现重叠.
结论:
- 准确的诊断和PVN的分类对于管理移植接受者至关重要.
- 将PVN与急性排斥区分开来,对于适当的治疗和改善移植存活是必不可少的.
相关概念视频
01:10Nephrons
2.4K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.4K
01:20Renal Corpuscle
2.0K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.0K