胃肠道研究中的饮食微生物群关联:系统性审查
Kerith Duncanson1,2,3, Georgina Williams1,2,3, Emily C Hoedt1,2,4
1NHMRC Centre of Research Excellence in Digestive Health, University of Newcastle, Newcastle, NSW, Australia.
Gut microbes
|May 10, 2024
概括
饮食和肠道微生物影响健康. 目前的饮食评估错过了微生物相关的营养素,阻碍了对饮食微生物群相互作用和个性化营养的理解. 为了更好的健康结果,需要取得进展.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 饮食评估 饮食评估
背景情况:
- 饮食和胃肠道微生物群的相互作用显著影响宿主健康和疾病的结果.
- 目前的饮食评估方法主要关注与人类消化相关的营养素,忽略了对微生物代谢至关重要的营养素.
- 准确量化与饮食相关的变量对于理解饮食与微生物群之间的关系至关重要.
研究的目的:
- 综合现有关于影响人类肠道微生物群的食物和营养素的研究.
- 识别饮食评估方法中的有关饮食与微生物群相互作用的知识差距.
- 为改善饮食评估的进展提供信息,以便更好地理解和应用饮食与微生物群的关系.
主要方法:
- 系统的文献搜索和证据综合.
- 包括38项系统性审查和106项主要研究,调查人类饮食与微生物群的关联.
- 对饮食因素的分析,包括饮食模式,巨量营养素,微量营养素,生物活性化合物和食品添加剂.
主要成果:
- 饮食因素显著改变结肠微生物群的组成和功能.
- 观察到的饮食与微生物群的关联主要涉及在小肠中吸收的营养物质,仅限于微生物群相关的营养物质.
- 微生物群相关的营养素在当前的食品成分数据库和饮食评估中不足.
结论:
- 在量化微生物群相关的饮食成分方面存在重大知识差距.
- 扩大食品成分数据库,包括微生物群相关数据,对于研究至关重要,特别是人类干预研究.
- 饮食评估方法的进步是必要的,以使微生物群特定的营养治疗.
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