衰老放大了肠道微生物群的免疫原体特征,与炎症加剧有关
Maria Elisa Caetano-Silva1,2, Akriti Shrestha2, Audrey F Duff3
1Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Aging cell
|May 10, 2024
概括
衰老会改变肠道微生物群,增加其引发炎症和疾病的潜力. 微生物免疫性中的这些变化与宿主炎症和老年人群对挑战的抵抗力降低有关.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 老年学是一门学科.
背景情况:
- 衰老与慢性低度炎症有关,增加了对感染和疾病的易感性.
- 肠道微生物群的组成随着年龄的增长而变化,影响免疫系统的功能.
- 驱动年龄相关炎症的机制和肠道微生物群的作用仍然不清楚.
研究的目的:
- 研究肠道微生物群作为衰老过程中低级炎症的驱动因素.
- 为了确定与衰老相关的微生物群免疫性转变是否直接影响宿主炎症.
- 探索老化肠道微生物群对抗生素治疗等挑战的弹性.
主要方法:
- 在老年小鼠中分析微生物组模式,屏障破坏和免疫透.
- 检测出活体免疫性测试,评估收费类受体 (TLR) 激活.
- 使用没有细菌的小鼠与来自老年和年轻捐赠者的微生物群进行殖民实验.
- 评估微生物群对广谱抗生素的反应.
主要成果:
- 年龄较大的小鼠显示细菌诱导的屏障破坏,免疫透,脂多糖结合蛋白 (LBP) 和结肠calprotectin的增加.
- 老老鼠的结肠和粘膜含量增强了激活托尔类受体4 (TLR4) 的能力.
- 殖民年轻的无菌小鼠与老化的微生物群增加了先天的炎症信号和内毒素.
- 衰老的微生物群对抗生素的反应发生了变化,治疗后持续升高埃斯赫里基亚菌和修改的TLR5免疫性.
结论:
- 衰老诱导肠道微生物群的转变,增加免疫性,导致低级炎症和内毒性.
- 这些与年龄相关的微生物群特征对挑战的抵抗力较低,并且与宿主炎症状况直接相关.
- 肠道微生物群的免疫性是与年龄相关的慢性炎症性疾病的关键因素.
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