在一般性焦虑症患者接受基于行为心理治疗后,炎症标志物发生变化:来自随机对照试验的证据
Lucas Gandarela1,2, Thiago P de A Sampaio2,3, Lia Marçal4
1Experimental Pathophysiology Program, School of Medicine, University of São Paulo, São Paulo, Brazil.
Brain, behavior, & immunity - health
|May 10, 2024
概括
基于接受的行为治疗没有改变一般性焦虑障碍 (GAD) 患者的炎症标志物. 虽然焦虑和抑郁症有所改善,但炎症和GAD之间的联系需要进一步调查.
科学领域:
- 精神病学和免疫学 精神病学和免疫学
- 行为科学 行为科学
背景情况:
- 通用焦虑症 (GAD) 与高C反应蛋白 (CRP) 和促炎细胞因子有关.
- 认知行为疗法 (CBT) 在临床焦虑症的炎症概况上显示出不同的结果.
研究的目的:
- 研究基于接受的行为疗法 (ABBT) 对GAD患者炎症生物标志物的影响.
- 为了比较ABBT对炎症的影响与支持性治疗 (ST) 作为活性对照.
主要方法:
- 77名GAD患者参加了一项为期14周的随机临床试验.
- 组ABBT (n=37) 或支持性组治疗 (ST,n=40) 进行.
- 测量了周围炎症生物标志物 (CRP,IL-1β,IL-4,IL-6,IL-10,TNF-α) 的情况.
主要成果:
- 在ST组,IL-1β降低;在ABBT组,IL-6增加.
- 没有观察到IL-4,IL-10,TNF或CRP水平的显著变化.
- 焦虑和抑郁症在两组都下降,IL-6/IL-10变化和焦虑评分之间存在负相关性.
结论:
- 一个简短的ABBT试验并没有改变与GAD相关的炎症前驱特征.
- 需要对其他炎症相关变量和更长的随访期进行进一步的研究.
- 支持性治疗对GAD外围炎症生物标志物的作用需要进一步研究.
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