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Updated: Jun 3, 2026

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
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所有光子激酶抑制剂:光控制释放和报告抑制

Cassandra L Fleming1,2, Carlos Benitez-Martin1, Elin Bernson3

  • 1Department of Chemistry and Chemical Engineering, Physical Chemistry, Chalmers University of Technology SE-41296 Göteborg Sweden a-son@chalmers.se.

Chemical science
|May 10, 2024
PubMed
概括

研究人员开发了光控制的LCK抑制剂,通过光来报告其活性. 这种全光子方法允许精确控制和监测细胞中的激酶抑制.

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Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...