异常的大脑拓组织和格兰格因果关系的连接在帕金森病与冲动控制障碍
Caiting Gan1, Heng Zhang1, Huimin Sun1
1Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Frontiers in aging neuroscience
|May 10, 2024
概括
帕金森病 (PD) 中的冲动控制障碍 (ICD) 与改变的白质组织有关. 患有ICD的患者表现出优化的大脑网络和异常连接,这表明奖励和运动回路的作用.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 冲动控制障碍 (ICD) 是帕金森病 (PD) 的常见神经精神疾病并发症.
- 白质 (WM) 拓组织对PD-ICD中大脑网络的影响尚不清楚.
研究的目的:
- 调查白质 (WM) 拓组织和脑网络连接在帕金森病患者和没有冲动控制障碍 (ICDs).
主要方法:
- 招募了17名患有ICD的PD患者 (PD-ICD),17名没有ICD的PD患者 (PD-NICD) 和18名健康对照 (HC).
- 采用图形理论和格兰杰因果关系分析来检查WM拓和定向连接模式.
主要成果:
- 与PD-NICD相比,PD-ICD患者表现出改变的全球WM特性 (减少最短路径长度,提高全球效率).
- 异常的节点拓参数在ICD组的左中间环状回环和左上小脑中被发现.
- 在PD-ICD患者中观察到,从左中间带带回形到右中间上额回形的方向连接性减少,与ICD严重程度相关.
结论:
- ICD患者表现出过度优化的WM拓和加强的奖励网络连接.
- 在皮质 - 边缘电路中的异常因果连接与帕金森病中ICDs的发展有关.
- 假设功能失调的奖励和运动抑制电路对于ICDs的出现至关重要.
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