一个注意力和工作记忆理论的幻觉脆弱性在前性痴呆症
Emma M Devenney1,2, Nga Yan Tse1,3, Claire O'Callaghan1,4
1Brain & Mind Centre, The University of Sydney, Sydney 2050, Australia.
Brain communications
|May 10, 2024
概括
在行为变异前性痴呆症 (bvFTD) 中的幻觉与注意力和视觉处理缺陷有关. 大脑成像揭示了前额叶皮质,尾状皮质,小脑和丘脑的结构变化,为bvFTD幻觉提供了一个新的模型.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经学 神经学
背景情况:
- 幻觉在行为变异前性痴呆症 (bvFTD) 中很常见,但其潜在机制尚不清楚.
- 了解这些机制至关重要,因为幻觉使bvFTD的诊断和管理复杂化.
- 现有的幻觉模型通常涉及认知和感知整合的失败.
研究的目的:
- 描述与bvFTD幻觉倾向相关的神经,认知和行为特征.
- 研究C9orf72基因扩张和幻觉亚型对这些特征的影响.
- 提出一种新的认知和神经模型,用于bvFTD中的幻觉倾向.
主要方法:
- 招募了153名bvFTD患者;一个幻觉的子组 (n=23) 与一个没有幻觉的bvFTD组 (n=23) 和健康的对照组 (n=23) 相匹配.
- 使用了详细的临床采访,全面的神经心理测试和体积核磁共振扫描.
- 分析了数据,重点关注神经结构,认知,行为,C9orf72扩展影响和幻觉亚型.
主要成果:
- 幻觉患者在基本和复杂的注意力和视觉功能方面表现较差 (P < 0.001).
- 结构性MRI揭示了幻觉者前额叶皮质,尾状皮质和小脑的显著变化.
- 患有幻觉的C9orf72载体表现出thalamic结构变化,而孤立的视觉幻觉与小脑缩有关.
结论:
- 注意力和视觉子系统,以及相关的大脑结构,都与bvFTD幻觉有关.
- 这些神经和认知相关物根据C9orf72状态和幻觉亚型而有所不同.
- 这些发现支持对bvFTD幻觉的新型认知神经模型,与神经精神疾病的跨诊断模型保持一致.
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