耐火性双极性抑郁症的治疗方法是用立体射线手术来治疗,这种手术的向是阴茎下阴茎皮层
Hugh B Solvason1, Neelan J Marianayagam2, Scott G Soltys3
1Department of Psychiatry, Stanford University School of Medicine, Stanford, USA.
Cureus
|May 10, 2024
概括
针对阴茎下环皮质 (SGC) 的立体射线外科手术 (SRS) 显示出治疗双相情感障碍严重抑郁症的前景. 三分之二的患者在这种非侵入性方法下经历了显著的症状改善.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经外科 神经外科
背景情况:
- 下阴带皮层 (SGC) 功能障碍与抑郁症有关.
- 对SGC的深度大脑刺激旨在使电路活动正常化并减轻抑郁症状.
研究的目的:
- 调查SGC的非除型立体射线手术 (SRS) 在降低局部代谢和抑郁症严重性的有效性.
- 评估SRS作为治疗耐治疗双极性抑郁症的治疗方法.
主要方法:
- 三名患有抗治疗双极性抑郁症的患者接受了双边SGC放射性手术 (75 Gy).
- 随访包括情绪评估 (HDRS,CGI),神经认知测试和多达两年的成像.
主要成果:
- 在三名受试者中,有两名获得了临床改善 (≥50%的HDRS减少).
- 没有观察到认知障碍;在两名患者中观察到无症状.
- 一名患者在药物停用后经历了躁狂发作,但恢复了.
结论:
- 对SGC的放射性手术向为严重的,耐治疗的双极性抑郁症提供了潜在的非侵入性策略.
- 有希望的结果需要进一步调查最佳目标选择和剂量.
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