是否设置的intradetrusor onabotulinumtoxinA注射用于管理过度活跃的膀物质?
James H Ross1, Megan Abrams2, Sandip P Vasavada3
1Center for Urogynecology and Pelvic Reconstructive Surgery, Cleveland Clinic, Obstetrics, Gynecology and Women's Health Institute, Cleveland, Ohio.
概括
对于过度活跃的膀 (OAB) 进行的intradetrusor onabotulinumtoxinA注射显示在办公室和手术室设置中都有很高的症状改善. 在手术室环境中,报告的改善率更高,但尿路感染的风险也更高.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 异常性过活性膀 (OAB) 影响了大量患者群体.
- 体内毒素A注射是对耐火性OAB的常见治疗方法.
- 程序可以在办公室或在手术室 (OR) 中进行.
研究的目的:
- 为了比较OAB患者的症状改善,这些患者接受了intradetrusor onabotulinumtoxinA注射.
- 根据手术是在办公室或OR环境中进行的,来评估结果.
主要方法:
- 多中心回顾性队列研究.
- 包括在2015年1月至2020年12月期间接受治疗的耐火性非神经性OAB妇女.
- 根据程序设置,将患者分为"在办公室"和"或"组.
主要成果:
- 包括539名患者:297人 (55%) 在办公室,242人 (45%) 在OR.
- 在办公室内组中,程序后保留的发生率更高 (8.1%对2.5%,P=0.003).
- 在OR组中尿路感染率较高 (26.0%对16.8%,P=0.009).
- 总体而言,主观改善率为77%.
- 或组报告了更大的改善 (81.4%对73.3%,P=0.03).
结论:
- 在OAB患者中,输入体体体体内毒素A注射产生了很高的主观改善.
- 设置 (在办公室和OR) 并没有显著改变整体治疗疗效.
- 考虑程序设置是很重要的,因为不同的并发症率 (保留与UTI).
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