在Telethon上的桃体:为A组链球菌 (GAS) 研究开发一个标准化的桃体照片集合
Marianne J Mullane1, Hannah M Thomas1, Jonathan R Carapetis1,2
1Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
Frontiers in pediatrics
|May 10, 2024
概括
这项研究使用标准化的照片评估了城市澳大利亚儿童的桃体大小,发现A组链球菌 (GAS) 喉炎的发病率较低. 这为了解GAS感染和风湿性心脏病风险提供了基线.
科学领域:
- 儿童传染病 儿童传染病
- 医学成像医学成像
- 公共卫生 公共卫生
背景情况:
- 包括喉炎在内的A组链球菌 (GAS) 感染可能导致诸如风湿性发烧和风湿性心脏病 (RHD) 等严重疾病.
- 在澳大利亚原住民和托雷斯海峡岛民群体中观察到高的RHD和GAS皮肤感染率,但GAS喉炎的患病率尚不清楚.
- 喉炎的临床症状,如桃体缩,在这些人群中是不常见的.
研究的目的:
- 开发一种使用桃体照片来评估儿童桃体大小的标准化方法.
- 确定西澳大利亚城市儿科人口中桃体大小的分布.
- 为了建立一个基线来比较桃体大小和澳大利亚不同人口中的GAS喉炎率.
主要方法:
- 在西澳大利亚珀斯招募了426名年龄在3-15岁的儿童.
- 两位独立的临床医生使用布罗德斯基分级尺度拍摄了桃体照片并对其进行了分级.
- 症状和A组链球菌抗原快速检测测试 (RADT) 被收集并与桃体分级相关联.
主要成果:
- 92%的参与者获得了高质量的桃体照片,其中79%被认为足够进行评估.
- 57%的照片得到了两位临床医生的相同评分,这表明对桃体大小的适度同意.
- 只有8%的人报告喉疼痛,并且不到1%的GAS RADT是阳性的,这表明这个城市队列中GAS喉炎的流行率很低.
结论:
- 这项研究表明,使用标准化桃体摄影来评估城市儿科患者桃体大小的可行性.
- 这些发现为与偏远土著社区等高风险群体比较桃体大小和GAS感染率提供了关键的概念验证.
- 这种标准化的方法可以帮助理解GAS喉炎的流行病学及其与澳大利亚风湿性心脏病的联系.
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