黑色素与德克斯梅德托米丁用于儿童在脑电图前诱导睡眠
Katja Peganc Nunčič1, David Neubauer1,2, Jasna Oražem Mrak1
1Department of Pediatric Neurology, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Frontiers in pediatrics
|May 10, 2024
概括
黑色素和德克斯梅德托米丁是安全的诱导儿童睡眠在EEG之前. 德克斯梅德托米丁比黑激素更有效,特别是在有复杂行为问题的儿童中,确保成功的EEG记录.
科学领域:
- 儿科神经学 儿科神经学
- 临床药理学 临床药理学
- 神经生理学神经生理学
背景情况:
- 儿童的脑电图 (EEG) 通常需要睡眠记录以进行准确的诊断.
- 自发睡眠并不总是可以实现的,需要药理干预.
- 在儿科EEG之前评估睡眠诱导的镇静剂至关重要.
研究的目的:
- 为了比较黑激素和德克斯梅德托米丁在接受EEG的儿童中诱导睡眠的安全性和有效性.
- 为了评估鼻内和舌下德克斯梅德托米丁与黑的对比.
- 分析一小组具有复杂行为问题的儿童的结果.
主要方法:
- 一项前性随机研究,涉及156名儿科患者 (1-19岁).
- 患者被随机分为三个组:黑激素 (0.1毫克/公斤),语言下德克斯梅托米丁 (3毫克/公斤) 或鼻腔内德克斯梅托米丁 (3毫克/公斤).
- 对效率和安全性参数进行了比较,包括对行为挑战的子组分析.
主要成果:
- 整体睡眠率很高 (93.6%在第一剂后,99.4%在第二剂后).
- 与氨酸 (83.3%) 相比,德克斯梅德托米丁的疗效显著更高 (99.0%) (p < 0.001).
- 鼻内用德克斯梅德托米丁导致睡眠开始速度比下舌处方更快 (p = 0.006);没有观察到呼吸抑制或心等不良事件.
结论:
- 黑激素和德克斯梅德托米丁在儿科EEG睡眠诱导中都是安全的.
- 德克斯梅德托米丁在有效性方面优于黑激素,包括在患有复杂行为问题的儿童中.
- 鼻内用德克斯梅德托米丁 (Dexmedetomidine) 提供了较快的睡眠开始,相比于语言下给药.
关键词:
这是一个EEGEEGEEGEEGEEG.德克斯梅德米丁 (Dexmedetomidine) 是一种制剂.电脑脑电图 (EEG) 是一种电脑电图.黑激素是什么意思 黑激素是什么意思睡眠 睡眠 睡眠 睡眠 睡眠诱导睡眠的诱导方式更多相关视频
09:57Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
2.6K
08:38Electroretinogram Recording for Infants and Children under Anesthesia to Achieve Optimal Dark Adaptation and International Standards
Published on: September 3, 2020
6.1K
相关概念视频
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
170
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
170
01:19Management of Insomnia
244
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
244
01:23Sedatives and Hypnotics: Overview
350
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
350