传播的 Mycobacterium colombiense 感染模仿恶性瘤:一个病例报告
1Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Heliyon
|May 10, 2024
概括
传播的Mycobacterium colombiense感染可以模仿癌症,延迟诊断. 甲基因组测序证实了罕见的菌根菌,使得有效的抗生素治疗和患者的恢复.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 哥伦比亚菌 (Mycobacterium colombiense) 是一种罕见的,生长缓慢的非结核菌.
- 它的临床表现可以模仿恶性瘤,带来诊断挑战.
研究的目的:
- 报告一个传播的Mycobacterium colombiense感染病例,最初被误诊为癌症.
- 突出元基因组下一代测序 (mNGS) 在诊断具有挑战性的传染病中的实用性.
主要方法:
- 最初的诊断工作包括成像,病因测试,骨髓活检和流细胞计.
- 通过元基因组下一代测序 (mNGS) 和从可触摸的质量中培养吸血液来实现最终诊断.
- 治疗涉及多种药物治疗方案,包括克拉里胺素,乙胺醇,利法和阿米卡.
主要成果:
- 综合调查排除了恶性瘤.
- 基因组下一代测序 (mNGS) 和培养证实了传播的Mycobacterium colombiense感染.
- 患者在处方的抗生素治疗方案中显示出显著的临床改善.
结论:
- 散布的Mycobacterium colombiense感染由于非特异性症状和可能模仿癌症的潜力,提出了诊断挑战.
- 基因组下一代测序 (mNGS) 是一种有价值的工具,用于快速和准确地诊断罕见的真菌细菌感染.
- 及时和准确的诊断至关重要,以避免误诊,治疗延迟,并确保有效管理Mycobacterium colombiense感染.
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