临界产科出血的风险评估 低分子量肝素的临界产科出血
Miho Akaishi1, Kunio Tarasawa2, Hirotaka Hamada1
1Department of Obstetrics and Gynecology, Tohoku University, Sendai, JPN.
Cureus
|May 10, 2024
概括
在分娩期间使用低分子量氨酸 (LMWH) 没有增加临界产科出血的风险,与未分离氨酸 (UFH) 不一样. 这表明LMWH是孕妇更安全的抗凝药选择.
科学领域:
- 产科和妇科 产科和妇科
- 药理学 药理学是指药理学的学科.
- 血液学 血液学 血液学
背景情况:
- 在分娩前期使用非分离式肝素 (UFH) 与更高的临界产科出血风险有关.
- 关于低分子量肝素 (LMWH) 在分娩期间的安全性的证据有限.
研究的目的:
- 调查在分娩期间使用低分子量肝素 (LMWH) 的安全性.
- 为了比较LMWH与其他抗凝药之间的临界产科出血风险.
主要方法:
- 日本全国医疗数据库 (2018-2022) 的回顾性分析.
- 包括从经历了分娩的妇女的数据.
- 统计分析包括调整的赔率比率 (aOR).
主要成果:
- 低分子量肝素 (LMWH) 与临界产科出血无关 (aOR,0.54).
- 在产科传播性血管内凝血 (DIC) 病例中,未分离的肝素 (UFH) 与严重出血有关 (aOR,3.91).
- 即使在剖腹产子组分析中,LMWH也没有显示增加风险.
结论:
- 不分离氨酸 (UFH) 的使用与急性产科出血的增加有显著联系.
- 低分子量肝素 (LMWH) 与急性产科出血增加无关.
- 对于妇女在分娩期间,LMWH似乎是一个比UFH更安全的抗凝药选择.
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