使用微流体系统模拟血液和淋巴血管
Eva Hall1, Kailee Mendiola, N Keilany Lightsey1
1Aerospace and Mechanical Engineering, Bioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Biomicrofluidics
|May 10, 2024
概括
微流体装置为研究血液和淋巴循环系统提供先进的体外模型. 这些模型使微循环动态和疾病机制的详细分析成为可能,有助于治疗发现.
科学领域:
- 生物医学工程 生物医学工程
- 生理学 生理学 生理学
- 微流体学 微流体学
背景情况:
- 循环系统 (血液和淋巴血管) 功能障碍与疾病有关.
- 在体内模型缺乏足够的监测和操纵微循环研究.
- 目前正在探索体外模型作为体外研究的替代方案.
研究的目的:
- 审查流体流动和循环系统中的电通信的生理行为.
- 评估用于研究微循环的体外微流体模型.
- 证明微流体系统在心血管和淋巴研究中的可行性.
主要方法:
- 对生理流体动力学和内皮细胞通信的审查.
- 对细胞共同培养和芯片器官技术的评估.
- 分析微流体设备模拟循环系统的能力.
主要成果:
- 微流体设备为微循环提供了生理上相关的模型.
- 这些系统允许详细描述流体动力学.
- 在体外模型有助于先进的研究分析.
结论:
- 微流体系统是用于心血管和淋巴研究的有价值的体外模型.
- 它们可以研究疾病机制和潜在的治疗方法.
- 这些模型为微循环研究提供了增强的实验工具.
相关概念视频
01:29Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
01:27Applications of Integration to Find Blood Flow
Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...