花油-固体脂质纳米颗粒的抗毒素的活性
Hanieh Mohammad Rahimi1, Zahra Hesari2, Elnaz Sadat Mirsamadi3
1Foodborne and Waterborne Diseases Research Center Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences Tehran Iran.
Food science & nutrition
|May 10, 2024
概括
腰油固体脂质纳米颗粒 (RhO-SLNs) 在治疗*毒素菌*感染方面表现有前途. 这些纳米粒子有效地向具有低毒性的寄生虫,提供了潜在的新治疗策略.
科学领域:
- 寄生虫学的寄生虫学
- 纳米技术 纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 毒素菌是一种广泛传播的寄生虫,会引起严重的健康问题,特别是在免疫力低下的人群中.
- 目前对毒素菌的治疗方法受到疗效和副作用的限制.
- 腰油 (RhO) 是一种天然化合物,具有各种有益的生物活性.
研究的目的:
- 为了评估腰油加载固体脂质纳米粒子 (RhO-SLNs) 的抗*Toxoplasma gondii*和细胞毒性作用.
- 探索纳米技术在为寄生虫感染提供天然化合物的潜力.
主要方法:
- 装有腰油 (RhO-SLNs) 的固体脂质纳米颗粒 (SLNs) 使用乳化声波同质化制备.
- 对 RhO-SLN 的表征包括粒子大小,泽塔潜力和捕获效率.
- 进行了体外分析,以评估抗*T. gondii*活性和对Vero细胞的细胞毒性.
主要成果:
- RhO-SLN的粒子大小为152.09nm,泽塔电位为-15.3mV,捕获效率为79.1%.
- 对*T. gondii*的抑制度 (IC50) 为>1μg/mL,表明具有显著的抗寄生虫活性.
- 细胞毒性度 (CC50) 为>10 mg/mL,对Vero细胞的毒性较低,在度>10 mg/mL时细胞活力为75%.
结论:
- RhO-SLNs显示出强烈的抗*毒素*活性,细胞毒性最小.
- 在SLN中封装天然化合物,如腰油,为开发抗 *T. gondii* 感染的新疗法提供了一个有希望的策略.
- 这种方法可以克服当前抗寄生虫药物的局限性.
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