在与食品接触材料中优先考虑双A的功能替代品的战略
Annick D van den Brand1, Ellen V S Hessel1, Rinus Rijk2
1Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Critical reviews in toxicology
|May 10, 2024
概括
建议禁止在食品接触材料 (FCM) 中使用双A (BPA). 研究人员优先考虑了20种BPA替代品,确定了其危险概况和使用方面的重大数据缺口,需要进一步的毒理学研究以防止令人遗憾的替代.
科学领域:
- 与食品接触材料的安全性食品接触材料的安全性
- 化学毒理学 化学毒理学
- 风险评估 风险评估 风险评估
背景情况:
- 双A (BPA) 是一种非常令人担忧的物质,欧盟建议禁止使用与食品接触材料 (FCM).
- 防止以危险的替代品取代令人遗憾的替代品至关重要.
- 在监管和科学文献中确定了300多种潜在的BPA替代品.
研究的目的:
- 制定优先级策略,以确定FCM中的安全BPA替代品.
- 评估不太熟悉的BPA替代品的危险概况和迁移潜力.
- 识别数据缺口,并为未来的研究和监测需求提供信息.
主要方法:
- 创建一个库存300多个潜在的BPA替代品.
- 制定优先级策略来选择关键物质.
- 对10种优先级物质的危险性和迁移数据进行科学文献审查和in silico选.
主要成果:
- 优先考虑了20种潜在的BPA替代品,其中10种被确定为不太熟悉的.
- 关于这些优先级物质的危险概况,存在重大数据缺口.
- 有限的数据表明,一些替代品 (例如,双TMC,4,4-二基二,四基甲) 的潜在危害,对其实际使用和暴露知之甚少.
结论:
- 严重的毒理学数据缺口阻碍了对潜在的BPA替代品的评估.
- 进一步的研究和监测至关重要,以防止用未知或类似危险性质的物质取代BPA.
- 为了避免令人遗憾的替代,需要对新出现的FCM物质进行全面的风险评估.
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