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肠道神经系统中的长期隐性表观遗传压力信息及其对IBS发展和延续的贡献
Császár-Nagy Noemi1,2, Petr Bob3, István Bókkon2,4
1National University of Public Services, H-1083 Budapest, Hungary.
Current neuropharmacology
|May 10, 2024
概括
怀孕期间的孕产妇压力可能会在胎儿肠道神经系统 (ENS) 中编程表观遗传记忆,这可能会通过微生物群-肠-大脑轴导致刺激性肠综合征 (IBS).
科学领域:
- 神经胃肠病学 神经胃肠病学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展规划是指发展规划.
背景情况:
- 精神病和情绪障碍与刺激性肠综合征 (IBS) 的发展和持续性有关.
- 一个先前的假设表明,肠道神经系统 (ENS) 中的压力诱导的表观遗传记忆有助于IBS,独立于中枢神经系统 (CNS).
研究的目的:
- 详细阐述这样一个假设:母亲的产前压力会在胎儿的ENS中产生表观遗传变化,从而影响IBS的发展.
- 探索微生物群-肠-大脑轴 (MGBA) 在将与压力相关的信息从胎儿的ENS传输到中枢神经系统中的作用.
主要方法:
- 该研究详细阐述了一个假设,整合了有关母亲压力,皮质醇,肠道微生物群和表观遗传机制的现有知识.
- 它讨论了母亲产前压力对胎儿HPA轴调节,肠道微生物群和肠道透性的潜在影响.
主要成果:
- 怀孕期间母亲的压力会改变胎儿的皮质醇水平,肠道微生物群和肠道透性.
- 微生物代谢产物可能会诱导表观遗传变化,将与压力相关的信息编程到胎儿的ENS.
- 胎儿内脏神经系统中编程的这些信息可以通过MGBA传输到中枢神经系统,影响大脑功能和情感过程.
结论:
- 产前应激暴露可能会在胎儿ENS中建立长期表观遗传记忆,从而导致IBS的发病.
- 双向MGBA在将与压力相关的表观遗传信息从ENS传递到中枢神经系统方面发挥着至关重要的作用.
- 这一途径突出了一个潜在的机制,将生命早期的压力与功能性胃肠道疾病和情绪障碍联系起来.
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