积极监测和新兴的医疗治疗选择为desmoid:什么时候和为谁?
Sylvie Bonvalot1, Aisha Miah2, Bernd Kasper3
1Department of Surgery, Institut Curie, Paris, France.
Current opinion in oncology
|May 10, 2024
概括
目前,主动监测是治疗瘤的主要策略,最近的试验证实了其有效性. 像索拉芬尼布这样的医疗治疗对进展性或复发性病例显示出希望.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 医学瘤学 医学瘤学
背景情况:
- 质瘤虽然是良性的,但可以引起显著的发病率.
- 管理策略已经发展,朝着不那么侵入性的方法发展.
研究的目的:
- 审查当前和不断发展的管理策略,对瘤的desmoid.
- 突出监测和医疗疗的最新进展.
主要方法:
- 对积极监视的回顾性和前性研究的审查.
- 对医疗治疗的最近随机对照试验的分析.
主要成果:
- 主动监测对初级外围瘤是有效的,其中约50%显示自发回归.
- 前性试验证实,在积极监测下,无进展的3年生存率为53.4-58%.
- 索拉费尼布,帕佐帕尼布和尼罗加塞塔特在进展性/复发性瘤中表现出临床活性.
结论:
- 积极监测被验证为desmoid瘤的主要管理方法.
- 新兴的医学疗法为患有进展性或复发性疾病的患者提供了新的选择.
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