使用基于心电图的深度学习预测和识别药物诱导的I型布鲁加达模式
Paul-Adrian Călburean1,2, Luigi Pannone1, Cinzia Monaco1
1Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, European Reference Networks Guard-Heart Brussels Belgium.
Journal of the American Heart Association
|May 10, 2024
概括
一个深层卷积神经网络,BrS-Net,准确地识别了布鲁加达综合征 (BrS) 的I型模式. BrS-Net还从基线心电图中预测了BrS的发展,有助于预防心脏突然死亡.
科学领域:
- 心脏病学 心脏病学
- 人工智能的人工智能
- 医学诊断 医学诊断 医学诊断
背景情况:
- 布鲁加达综合征 (BrS) 与健康个体的突然心脏死亡有关.
- 药物诱导的BrS占所有BrS病例的很大一部分 (55-70%).
研究的目的:
- 开发和评估用于布鲁加达综合征诊断的深 convolutional 神经网络 (CNN).
- 评估CNN识别和预测BrS类型I模式的能力.
主要方法:
- 波形分析从基线和阿贾马林输液中转换了心电图跟踪.
- 一个称为BRS-Net的CNN受过训练,能够识别和预测BRS I型模式.
- 该研究包括1188名接受阿贾马林测试的患者.
主要成果:
- 在阿贾马林期间,BrS-Net在识别BrS I型模式方面取得了很高的性能 (AUC-ROC 0.945,AUC-PR 0.892).
- 从基线心电图 (AUC-ROC 0.805,AUC-PR 0.605) 来看,BrS-Net显示了从基线心电图 (AUC-ROC 0.805,AUC-PR 0.605) 来看BrS I型发育的良好预测性能.
- 30.3%的患者在阿贾马林输液期间出现了BrS型I模式.
结论:
- BrS-Net有效地识别了高准确度的 BrS I 类型模式.
- BrS-Net在预测未经选择的人群中基线ECG的BrS发展方面表现有前途.
相关概念视频
01:29Electrocardiogram
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An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
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01:28Electrocardiogram Fundamentals
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Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
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01:16ECG Interpretation of Arrhythmias I: Sinus Arrhythmias
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Arrhythmias are disturbances in the heart's rhythm that lead to abnormal heartbeats. These irregularities can originate from different parts of the heart and are classified based on their origin and nature.
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Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
Types of Arrhythmias
Sinus Node Arrhythmias
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01:30Cardiac Action Potential
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Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
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Ionic Basis of Cardiac Action Potentials
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Ionic Basis of Cardiac Action Potentials
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01:25Correlation between ECG and Cardiac Cycle
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A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
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