在种族和民族群体中,家族史与早期心房动之间的关联
Anish S Shah1,2, Ana Ongtengco1, Victor Qiao3
1Division of Cardiology, Department of Medicine University of Illinois Chicago Chicago IL.
Journal of the American Heart Association
|May 10, 2024
概括
有心房动脉节律失常的家族病史会增加早期心房的风险 (EOAFL). 这项研究突出了各种不同人群中可能导致EOAFL的遗传因素.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 早期心房的遗传因素主要研究在欧洲人群中.
- 人种和家族病史在早发性心房 (EOAFL) 中的作用尚不清楚.
研究的目的:
- 调查家族病史与EOAFL的发生之间的关联.
- 探索与EOAFL相关的种族和临床风险因素.
主要方法:
- 一项横截面研究招募了909名通过心电图确认的心房动 (AFL) 患者.
- 通过问卷和面试来评估家庭病史.
- 早发性心房 (EOAFL) 被定义为在66岁之前诊断的AFL.
主要成果:
- 阳性家族病史与EOAFL的可能性更高有关 (OR,1.8).
- 黑人种族 (OR,2.1),酒精使用 (OR,1.6) 和阻塞性睡眠呼吸暂停 (OR,1.9) 与EOAFL的几率增加有关.
- 使用某些心脏药物与EOAFL的几率较低有关.
结论:
- 研究结果表明,在不同种族和族群中,对EOAFL的遗传性倾向存在.
- 对心房的遗传基础进行进一步的研究是有必要的.
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