海尔明斯以依赖IL-9的方式减轻COVID-19相关的细胞因子风暴
Zengguo Cao1,2, Jiaqi Wang1, Xiaolei Liu1
1State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
mBio
|May 10, 2024
概括
虫感染Trichinella spiralis通过增强互白素-9 (IL-9) 来保护COVID-19中的细胞因子风暴. 这种IL-9通路为严重感染和炎症提供了一种新的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 类动物学 类动物学
背景情况:
- 严重的COVID-19的特征是细胞因子风暴,由TNF-α和IFN-γ等促炎性1型细胞因子驱动.
- 已知虫调节免疫反应,可能减轻过度炎症.
- 了解控制细胞因子风暴的机制对于管理严重传染病至关重要.
研究的目的:
- 研究虫Trichinella spiralis (Ts) 感染对TNF-α和IFN-γ诱导的冲击的保护作用.
- 阐明白蛋白-9 (IL-9) 在Ts介导保护中的作用.
- 在SARS-CoV-2感染模型中评估IL-9和Ts分泌/分泌 (TsES) 产品的治疗潜力.
主要方法:
- 在小鼠中诱导TNF-α和IFN-γ冲击以模拟细胞因子风暴.
- 小鼠感染Trichinella spiralis (Ts) 和评估生存率.
- 用重组IL-9和Ts分泌/分泌 (TsES) 产品治疗,在小鼠模型中对冲击和SARS-CoV-2感染进行治疗.
主要成果:
- Ts感染提供了对TNF-α和IFN-γ诱导的冲击的保护,依赖于IL-9.
- 重组IL-9治疗改善了经历冲击的小鼠和SARS-CoV-2感染模型 (K18-hACE2小鼠) 的生存率.
- 分泌/分泌 (TsES) 产品也表现出对SARS-CoV-2诱导的细胞因子风暴的保护作用.
结论:
- 介乐-9 (IL-9) 在虫介导的防护中起着关键作用,对抗细胞因子风暴综合征.
- IL-9代表了缓解COVID-19等感染中严重炎症的重要治疗标.
- 来自Ts分泌/分泌产品的抗炎分子为开发新型治疗提供了有前途的途径.
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