花在放射治疗后对唾液腺的影响
Ibrahim Erdim1, Sefa Colak2, Mustafa Sami Demirsoy2
1Otorhinolaryngology Department, Medical Faculty, Health Sciences University, Sancaktepe Sehit Prof. Dr. Ilhan Varank Education and Training Hospital, Istanbul, Türkiye.
The Journal of craniofacial surgery
|May 10, 2024
概括
蜂补充剂通过增加抗氧化剂水平和水素素表达以剂量依赖的方式保护唾液腺免受放射治疗损伤,这表明它具有治愈作用.
科学领域:
- 生物医学研究的研究.
- 辐射疗法对辐射疗法的影响
- 自然产品药理学 自然产品药理学
背景情况:
- 头癌的放射治疗 (RT) 可能会损害唾液腺.
- 唾液腺功能障碍显著影响患者的生活质量.
- 调查唾液腺的保护剂至关重要.
研究的目的:
- 评估不同剂量 прополис对接受RT的唾液腺的保护作用.
- 评估 прополис对受RT影响的唾液腺体中氧化应激标志物和水素表达物的影响.
主要方法:
- 鼠被分为对照组和三个实验组,分别接受不同剂量 прополис (100 mg/kg/ml和 200 mg/kg/ml) 的RT.
- 免疫组织化学被用来分析水素-1 (AQP-1) 和水素-5 (AQP-5) 的表达.
- 生物化学测定测量了马隆迪阿尔海德 (MDA),超氧化物脱酶 (SOD),谷氨过氧化酶 (GPO),总抗氧化剂状态 (TAS) 和总氧化剂状态 (TOS).
主要成果:
- 以剂量取决的方式, administration显著增加了抗氧化剂标志物 (GPO,SOD,TAS) 和降低了氧化应激标志物 (MDA,TOS).
- 与仅接受RT治疗的组相比,粉治疗组的水素-1和水素-5表达水平更高.
- 在较高剂量的 прополис时,观察到最高的保护作用.
结论:
- прополис在放射治疗损伤的唾液腺上表现出剂量依赖的愈合作用.
- 蜂增强了抗氧化能力,并减少了RT后唾液腺的氧化应激.
- 增加的水素表达表明,随着治疗,唾液腺功能得到改善.
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