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输注IGF-1会增加胎儿羊的生长,当欧胰岛素血症维持时

Jane Stremming¹, Eileen I Chang¹, Alicia White¹

¹Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

The Journal of endocrinology

|May 10, 2024

概括

在胎儿胰岛素样生长因子1 (IGF-1) 输注期间维持胰岛素和葡萄糖水平对于最大限度地提高胎儿生长至关重要. 这支持羊模型的整体胎儿发育和器官体重.

科学领域:

周围生理学周围生理学
胎儿生理学胎儿生理学
内分泌学在内分泌学.

背景情况:

胰岛素类生长因子1 (IGF-1) 是一个关键的胎儿合成激素.
单独给胎儿羊注入IGF-1会增加器官体重,但不会持续增加体重.
输注IGF-1降低胎儿胰岛素,可能限制生长.

研究的目的:

调查IGF-1输注期间维持欧胰岛素血症和高血糖症对胎儿生长的影响.
为了确定联合IGF-1和胰岛素/乳糖输注是否与单独的IGF-1或对照剂相比增强胎儿生长.

主要方法:

妊娠晚期的胎儿羊接受了IGF-1 (IGF),IGF-1与胰岛素和乳糖 (IGF+INS) 或载体控制 (CON) 的静脉注射一周.
代谢研究测量了输注前后的子宫和节营养素和氧气吸收.
评估了胎儿的体重和器官重量.

主要成果:

IGF+INS胎儿比CON胎儿重23%,心脏,肝脏和上腺更重.
IGF+INS胎儿显示带氧气和必需氨基酸吸收增加.
与IGF+INS和CON组相比,仅IGF输注显著降低了胎儿胰岛素水平.

结论:

在胎儿IGF-1输注期间维持欧胰岛素血症和euglycemia对于最大的胎儿身体生长至关重要.
IGF-1和胰岛素可能刺激胎盘营养物质的运输,以支持胎儿的发育.
这项研究强调了IGF-1和胰岛素在促进胎儿生长中的协同作用.

关键词:

氨基酸是氨基酸中的一种.胎儿的成长胎儿的成长在这种情况下,胰岛素胰岛素胰岛素.类似胰岛素的增长因子1 胎盘营养物质的运输

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