喉外区域的微生物组成:系统性审查
Zara Sragi1, Vikram Vasan1, Benjamin M Laitman1
1Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine, New York, New York, 10029, U.S.A.
上呼吸道微生物群,特别是喉和气管,对健康和疾病至关重要. 这些地区的失生症会影响各种疾病,强调需要进一步的研究和潜在的治疗干预措施.
科学领域:
- 微生物学 微生物学
- 上空气道研究研究
- 疾病的病原发生 疾病的病原发生
背景情况:
- 微生物组研究在历史上一直专注于口腔和口腔大.
- 喉和气管的微生物群落仍然没有得到充分的研究.
- 了解这些上呼吸道微生物群是解读疾病影响的关键.
研究的目的:
- 审查和评估喉喉内微生物组成.
- 为了比较健康和疾病状态中的微生物群落.
- 为了确定失生症在上呼吸道条件中的作用.
主要方法:
- 对EMBASE,MEDLINE和Cochrane Central数据库进行系统审查.
- 包括使用下一代16s核糖体测序的研究.
- 对10项专注于喉和气管微生物组的研究进行了分析.
主要成果:
- 健康的喉有各种各样的物种,如链球菌和Prevotella.
- 良性喉疾病显示多样性减少,通常由链球菌主导.
- 喉状细胞癌与多样性的增加有关,特别是Fusobacterium.
- 气管微生物群的多样性随着糖尿病和下呼吸道感染等疾病而变化.
- 肺炎中的特定微生物概况与生存和输出成功相关.
结论:
- 喉微生物群是独一无二的,受到良性和恶性疾病的影响.
- 需要进一步的研究来探索各种喉外病变.
- 针对微生物组的治疗方法可能会提供新的治疗策略.
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