乳腺癌免疫景观:系统免疫和局部免疫之间的相互作用
Tatiana Gerashchenko1, Anastasia Frolova2,3, Marina Patysheva1
1Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str. 5, Tomsk, 634009, Russia.
Advanced biology
|May 10, 2024
概括
本综述探讨了免疫系统在乳腺癌 (BC) 中的复杂作用,详细介绍了系统和局部免疫反应如何影响瘤进展,并可能影响免疫治疗的有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 乳腺癌 (BC) 是全球女性的主要恶性瘤.
- 免疫系统在癌症的发展和进展中起着至关重要的作用.
- 瘤与免疫系统的相互作用是复杂的,瘤能够逃避免疫监测.
研究的目的:
- 提供乳腺癌患者免疫特征的全面审查.
- 阐明瘤进展中的全身和局部免疫反应之间的相互作用.
- 讨论先天性和适应性免疫细胞在乳腺癌中的功能性作用.
主要方法:
- 关于免疫瘤学和乳腺癌研究的综合文献综述.
- 分析乳腺癌中的全身和局部免疫反应.
- 讨论免疫细胞群的功能活动.
主要成果:
- 免疫系统在乳腺癌中具有双重作用,可能促进或抑制瘤生长.
- 瘤微环境和系统性免疫反应相互关联,影响瘤的进展.
- 特定的免疫细胞种群有助于BC的前瘤或抗瘤免疫力.
结论:
- 了解乳腺癌中的全身免疫特征至关重要.
- 局部和全身免疫之间的相互作用为瘤进展提供了洞察力.
- 这一审查可以指导开发用于乳腺癌治疗的新型免疫疗法.
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