双双胞胎怀孕的结果与融合与分离的胎盘相比
Sarah Aldhaheri1, Vasilica Stratulat1, Nir Melamed2
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Archives of gynecology and obstetrics
|May 10, 2024
概括
在二双胞胎怀孕中,融合的胎盘降低了妊娠前的风险,但增加了胎儿生长限制. 这一发现可能有助于预测妊娠并发症.
科学领域:
- 孕产妇和胎儿的医学
- 周围生理学 周围生理学
- 产科 产科 产科 产科 产科
背景情况:
- 融合的胎盘发生在二二双胞胎怀孕的子集中.
- 双双胞胎融化胎盘的临床意义尚未得到充分证实.
- 早期识别化胎盘可能有助于风险评估.
研究的目的:
- 为了比较二子双胞胎怀孕与融合胎盘与单独胎盘之间的妊娠结果.
- 为了确定融化胎盘与不良妊娠结果 (如胎儿生长限制和子宫前症) 之间的联系.
主要方法:
- 对二子双胞胎 (2014-2022) 的回顾性队列研究.
- 分析的结果包括胎儿生长限制和孕前.
- 多变量波松回归用于估计调整后相对风险 (aRR) 和95%置信区间 (CI).
主要成果:
- 在328例二生双胞胎怀孕中,53.4%的孕妇中发现了融化的胎盘.
- 融化胎盘与更低的孕前风险 (aRR 0.48) 相关,但胎儿生长限制风险更高 (aRR 1.23).
- 胎盘化的孕妇显示新生儿重症监护室入院的风险增加 (aRR 1.31) 和胎盘总重量降低 (aRR 1.93).
结论:
- 双胞胎怀孕与融化的胎盘有降低了子宫前的风险.
- 融化胎盘与胎儿生长限制的可能性增加有关,可能是由于胎盘质量较低.
- 合并的胎盘可以作为双双胞胎怀孕并发症的预测生物标志物.
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