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Updated: Jun 26, 2025

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柱状细胞甲状腺癌:一种异构的实体,表明乳头甲状腺癌和毛囊性新生体之间的重叠
Kathleen E Higgins1, Peter M Sadow2, Daniel N Johnson3
1College of Dentistry, The University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Head and neck pathology
|May 10, 2024
概括
柱状细胞皮质甲状腺癌 (CC-PTC) 呈现出多样化的遗传特征和临床行为. 一些CC-PTC案件表现出积极的特征,而另一些则是惰的,这表明潜在的重新分类.
科学领域:
- 内分泌学和瘤学的内分泌学和瘤学.
- 分子病理学分子病理学
- 甲状腺癌研究研究
背景情况:
- 柱状细胞乳头甲状腺癌 (CC-PTC) 是乳头甲状腺癌的形态亚型,预后可变.
- CC-PTC的特征是瘤甲状腺毛囊细胞具有伪层化柱状形态.
- CC-PTC的分子形状和临床结果需要进一步阐明.
研究的目的:
- 综合分析CC-PTC的形态,免疫组织化学和遗传特征.
- 将这些特征与临床结果和患者预后相关联.
- 根据其独特的特征,调查CC-PTC重新分类的可能性.
主要方法:
- 对来自三个机构的12个CC-PTC案件 (2006-2023) 的回顾性分析.
- 对于雌激素受体 (ER) 和CDX的免疫组织化学2.
- 包括DNA和RNA测序在内的全面分子测试.
主要成果:
- 确定了12例成年病例,其中2例呈现出甲状腺外疾病,2例具有远程转移.
- 在TERT促进体,RAS,ATM,NOTCH1,APC和ESR1中发现了致病突变,以及AGK::BRAF融合和NF2损失.
- 分别在73%和50%的病例中观察到ER和CDX2阳性;高度形态与较差的结果相关.
结论:
- CC-PTC代表了一组基因和行为异质的瘤.
- 瘤的行为有显著的变化,非侵入性/最小侵入性病例显示缓慢的过程.
- 显著的遗传多样性,形态学和临床行为表明CC-PTC可能需要重新分类,与乳头甲状腺癌亚型分开.
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