接受免疫治疗的癌症老年患者中毒性:一项观察性研究
Estelle Tran Van Hoi1, Stella Trompet2, Yara Van Holstein2
1Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. e.tran_van_hoi@lumc.nl.
Drugs & aging
|May 10, 2024
概括
在接受免疫治疗的老年癌症患者中,增加的虚弱与更高的毒性风险,住院和停止治疗相关. 在有较低毒性等级的患者中,也出现了早期停止治疗的情况,这表明耐受性降低.
科学领域:
- 老年瘤学 老年瘤学
- 免疫治疗是一种免疫疗法.
- 癌症治疗方法 癌症治疗方法
背景情况:
- 检查点抑制剂是老年人有效的癌症治疗方法.
- 年长的癌症患者是一个异质的群体,他们的脆弱性,认知和身体状况各不相同.
研究的目的:
- 调查临床脆弱性与免疫相关治疗毒性之间的关联.
- 在接受检查点抑制剂的老年患者中,检查虚弱与住院和因毒性而中止治疗之间的联系.
主要方法:
- 分析了使用检查点抑制剂治疗的来自三项研究 (TENT,IMAGINE,耐受性和免疫疗法的安全性) 的70岁以上患者.
- 临床脆弱性是使用老年-8测试和世界卫生组织 (WHO) 绩效状态来评估的.
- 结果包括3-5级毒性,住院和与免疫相关的不良事件相关的治疗中止.
主要成果:
- 99名患者中有33%的身体虚弱 (老年-8分数<15分).
- 虚弱的患者 (异常的老年人-8或更高的世卫组织得分) 显示出更高的毒性概率,治疗中止和住院的趋势.
- 在有较低毒性等级 (1-2) 的患者中也观察到早期停止治疗.
结论:
- 接受免疫治疗的老年癌症患者的脆弱性增加与毒性增加,住院和停止治疗的趋势有关.
- 需要进行更大规模的研究来证实这些探索性发现.
- 具有较低毒性等级的老年患者的耐受性可能会降低,导致频繁的早期中止治疗.
相关概念视频
01:27Tumor Immunotherapy
518
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
518
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K