拉莫特里金的水合物和溶酸盐中的超分子合成子:用于共晶设计的工具
Gordana Pavlović1, Edislav Lekšić2, Ernest Meštrović3
1Department of Applied Chemistry, University of Zagreb Faculty of Textile Technology, Prilaz baruna Filipovića 28a, Zagreb, 10000, Croatia.
概括
抗药物lamotrigine (LAM) 由于其结合能力,很容易形成多组分固体. 其特有的超分子合成子适应新结构,证明了LAM.
科学领域:
- 晶体工程 晶体工程
- 材料科学 材料科学 材料科学
- 药用化学 医学化学
背景情况:
- 拉莫特里金 (LAM) 是一种抗药物,具有形成多组分固体的倾向.
- 这种行为归因于LAM内部能够形成键的多种化学组的存在.
研究的目的:
- 为了研究新的拉莫特里金水合物和溶酸盐的形成.
- 为了分析lamotrigine晶体结构中已知的超分子合成子的强度.
- 了解拉莫特里金在竞争性结环境中形成有序固态超分子架构的易感性.
主要方法:
- 合成一种新的水合物和11种lamotrigine溶解物.
- 合成化合物的比较固态结构分析.
- 超分子合成子及其拓结构的识别和描述.
主要成果:
- 该研究成功合成了一种新的水合物和11种lamotrigine溶酸盐.
- 阿米诺皮里丁二元组合组合 (synthon 1) 主要从para-para转移到正正顶层,除了一个例子外.
- 同位素2通过充当异位素的作用来适应,并结合了溶剂分子.
结论:
- 拉莫特里金在形成各种固态超分子结构方面表现出显著的适应性.
- 已识别的synthons是强大的,但灵活的,允许基于lamotrigine的多组件固体的可预测的晶体工程.
- 了解这些相互作用对于设计具有量身定制性质的lamotrigine新的固体形式至关重要.
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