在类风湿性关节炎中,牙周炎与血清抗马隆二甲-乙二甲酸抗体度之间的关联:一项病例对照研究
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Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
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Joyce A Lee1, Ted R Mikuls2,3, Harlan R Sayles4
1Department of Surgical Specialties, Division of Periodontics, College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska, USA.
Journal of periodontology
|May 10, 2024
概括
马隆迪甲-乙甲 (MAA) 添加物与类风湿性关节炎 (RA) 和牙周病有关. 在RA患者中,较高的膜骨损失与特定的抗MAA抗体相关,这表明MAA在RA病变发生中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 牙周病学 牙周病学
背景情况:
- 马隆迪甲基-乙甲基 (MAA) 添加物与类风湿性关节炎 (RA) 和牙周病的发病有关.
- 在RA和炎症的牙周组织中发现了抗MAA自身抗体.
- 这项研究调查了 RA 患者和骨关节炎 (OA) 控制中的牙周健康,膜骨损失 (ABL) 和抗MAA抗体之间的联系.
研究的目的:
- 量化牙周临床测量,ABL和特定口腔细菌抗体度与抗MAA抗体水平之间的关联.
- 探索抗MAA抗体和牙周病标志物在RA和OA之间的关系.
主要方法:
- 分析了来自284例RA病例和330例OA对照的血清样本.
- 进行了牙周临床评估和膜骨损失 (ABL) 测量.
- 酶相关免疫吸收试验 (ELISA) 量化了血清免疫球蛋白 (Ig) A,IgG和IgM抗MAA和IgG抗菌抗体度.
主要成果:
- 在一般牙周测量和血清抗MAA抗体之间没有发现显著的关联.
- 在RA患者中,中度和高的ABL (但不是OA) 与IgG和IgM抗MAA抗体呈阳性关联.
- 对 Porphyromonas gingivalis,Prevotella intermedia 和 Fusobacterium nucleatum 的抗体度与各种抗MAA抗体同型 (IgA,IgG,IgM) 有积极关联.
结论:
- 在RA患者中,ABL和血清IgG/IgM抗MAA抗体之间存在独特的积极关联,在OA中没有发现.
- 口服细菌抗体水平与RA和OA组中的抗MAA抗体有显著的关联.
- 这些发现表明MAA在牙周健康和RA之间的复杂相互关系中可能发挥作用.
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