在认知上正常的成年人中CAIDE评分,阿尔茨海默病病理学和认知:CABLE研究
Ze-Xin Guo1, Fang Liu2, Fang-Yuan Wang1
1Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Journal of Alzheimer's disease : JAD
|May 10, 2024
概括
心血管风险因素,衰老和痴呆症 (CAIDE) 评分预测痴呆症风险. 较高的CAIDE分数与病理和认知衰退的增加有关,而则调解了这种关系.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 认知科学 认知科学
背景情况:
- 心血管风险因素,衰老和痴呆 (CAIDE) 风险评分是痴呆风险的验证预测指标.
- 关于CAIDE得分与阿尔茨海默病 (AD) 病理学之间的关联的研究是有限的.
研究的目的:
- 调查CAIDE得分和脑脊液 (CSF) AD生物标志物之间的关系.
- 为了检查CAIDE得分和中国队列的认知表现之间的关联.
主要方法:
- 中国阿尔茨海默病生物标志物和生活方式 (CABLE) 研究包括600名认知正常的参与者.
- 多种线性回归模型被用来分析CAIDE得分,AD CSF生物标志物和认知得分之间的相关性.
- 进行调解分析以评估AD病理是否调解CAIDE得分和认知表现之间的关联.
主要成果:
- 更高的CAIDE得分与tau生物标志物 (pTau,tTau,tTau/Aβ42) 有积极的相关性.
- CAIDE评分与认知表现 (MMSE,MoCA评分) 有负相关性.
- 陶病理部分调解了CAIDE得分和认知表现之间的关系 (3.2%13.2%调解).
结论:
- 较高的CAIDE分数与病理增加和认知功能下降有关.
- 病理在CAIDE得分和认知衰退之间的联系中起着调解作用.
- 这表明,CAIDE评分所表明的痴呆风险增加,通过加速的神经退行导致认知障碍.
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