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Updated: May 7, 2026

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
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聚纳米粒子平台 (PARCELs) 用于体外和体外mRNA输送

Yutian Ma1, Palas B Tiwade1, Rachel VanKeulen-Miller2

  • 1Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Nano letters
|May 10, 2024
PubMed
概括

聚纳米平台 (PARCELs) 通过克服内体捕获来改善mRNA传递,这是脂质纳米粒子 (LNPs) 的一个关键挑战. PARCELs证明了更安全,更有效的mRNA治疗方法的优越内体逃生.

关键词:
交付平台的交付平台.细胞内体逃脱的方法脂质纳米颗粒的使用方法它们是mRNARNA.聚醇是一种多醇.

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