关于早期和当前运动异常和精神病类似症状的发展视角
Jessica Fattal1, Maksim Giljen2, Teresa Vargas3
1Department of Psychology, Northwestern University, Evanston, IL, USA.
Schizophrenia bulletin
|May 10, 2024
概括
早期发育迟缓与青少年的感觉运动缺陷有关,增加了精神病类似经历 (PLEs) 的风险. 这些发现强调了运动标志是精神病脆弱性的关键因素.
科学领域:
- 神经发育障碍 神经发育障碍
- 精神病学是一个精神病学.
- 认知神经科学 认知神经科学
背景情况:
- 类似精神病的经历 (PLEs) 是常见的,代表了精神病脆弱性的范围.
- 运动征兆是精神疾病的特征,但它们的发育轨迹和与PLEs的关系尚未完全理解.
研究的目的:
- 调查早期生活里程碑的延迟与青少年当前感官运动功能之间的关系.
- 检查这些因素如何与积极和消极的精神病类经历 (PLEs) 相关.
主要方法:
- 利用了来自费城神经发育队列的7559名青少年 (11至21岁) 的数据.
- 评估当前的传感动力功能,使用计算机指触任务 (电机减速) 和鼠标练习任务 (传感动力规划).
主要成果:
- 早期发育迟缓与青少年的运动减缓和感觉运动规划受损有显著的关联.
- 显著的相互作用表明,早期发育迟缓的个体在感觉运动功能障碍和PLE之间表现出更强的联系.
- 与早期和当前感觉运动功能障碍独立治疗的模型相比,相互作用模型更好地解释了当前的PLEs.
结论:
- 早期发育迟缓和当前的感觉运动功能与精神病易感性有关.
- 这些发现支持了运动回路的神经发育视角和精神病中异型连续性的概念.
- 运动标志似乎是精神病连续和脆弱性的核心特征.
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