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Updated: Jun 26, 2025

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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CD8+ 针对由HLA-E呈现的瘤抗原的T细胞向

Ravi F Iyer1, Marieke C Verweij1, Sujit S Nair2

  • 1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.

Science advances
|May 10, 2024
PubMed
概括

使用细胞巨乳病毒 (CMV) 载体的癌症疫苗可以产生针对瘤抗原的MHC-E受限CD8+ T细胞. 这些T细胞可以识别并响应表达MHC-E的癌细胞,提供一种新的免疫治疗方法.

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