一个乳酸-SREBP2信号轴驱动宽容性树突细胞成熟,并促进癌症进展

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Updated: Jun 26, 2025

Author Spotlight: Dendritic Cells Maturation Using Sialidases-Based Enzymatic Treatment of the Cell Surface
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Published on: October 20, 2023

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Michael P Plebanek1, Yue Xue1, Y-Van Nguyen1

  • 1Department of Medicine, Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA.

Science immunology
|May 10, 2024
PubMed
概括

瘤细胞产生调节性树突细胞 (DCs),抑制抗癌免疫力. 在DC中抑制SREBP2通路可以增强抗瘤T细胞的反应,并减缓黑色素瘤的生长.

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