香烟薄荷含量变化对急性尼古丁药理学和吸烟拓学的影响
Hristina Dimova1, Megan J Schroeder1, Wallace B Pickworth2
1Food and Drug Administration, Center for Tobacco Products, Office of Science, Calverton, MD, USA.
概括
薄荷烟可以增强薄荷吸烟者的吸烟乐趣,但短期内不会显著改变尼古丁的药理动力学或地形学. 较高的薄荷含量可能会减少吸气,而中等水平可以改善主观体验.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 烟草科学 烟草科学
- 行为科学 行为科学
背景情况:
- 薄荷醇是香烟中的关键添加剂,影响吸烟吸引力和成.
- 现有的关于薄荷醇对尼古丁药理动力学 (PK) 和吸烟拓学的影响的研究是不一致的.
- 这项研究旨在澄清薄荷醇对尼古丁药理学和薄荷醇吸烟者的吸烟行为的影响.
研究的目的:
- 调查香烟中各种薄荷度 (0,3,6,12毫克) 对尼古丁PK,吸烟地形和主观体验的影响.
- 为了评估薄荷醇对尼古丁吸收和吸烟模式的影响,目前的薄荷醇香烟使用者.
- 了解薄荷醇含量如何影响吸烟期间的用户偏好和感官感知.
主要方法:
- 采用了一种双盲,随机,四期交叉研究设计.
- 在受控的会议中,参与者吸食不同含量薄荷醇的香烟 (0,3,6,12毫克).
- 尼古丁PK通过连续血液样本测量,并使用CReSS实验室设备记录吸烟地形.
主要成果:
- 在处方吸烟后,没有观察到薄荷对尼古丁PK的显著影响.
- 在ad libitum吸烟期间,更高的薄荷醇 (12毫克) 导致更小的吸烟量和持续时间.
- 温和的薄荷醇水平 (3-6毫克) 与0毫克相比,导致更积极的主观评分,而12毫克不太喜欢和更苛刻.
结论:
- 在市场度 (3-6毫克) 的薄荷醇可增强薄荷醇使用者的主观吸烟体验.
- 剧烈暴露于不同的薄荷醇水平并没有显著改变尼古丁的药理效应或吸烟地形.
- 薄荷醇的感官特性有助于产品偏好,并可能促进吸烟的开始和依赖.
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