怀孕期间是否可以识别COVID-19感染相关的生物标志物? :一项针对土耳其人口的前性研究
İlke Özer Aslan1, Keziban Doğan2, Alev Kural3
1Department of Obstetrics and Gynecology, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, Türkiye.
Medicine
|May 10, 2024
概括
生物标志物如C反应蛋白 (CRP),血小板与中性粒细胞比率 (PNR) 和血小板与淋巴细胞比率 (PLR) 可能有助于预测2019年冠状病毒病 (COVID-19) 在孕妇中的进展. 需要进一步的研究来证实这些发现.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 临床免疫学临床免疫学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 对孕妇构成风险.
- 怀孕期间COVID-19的预测生物标志物对于疾病管理至关重要.
- 复合血液图和炎症标志物是潜在的指标.
研究的目的:
- 为了确定预测孕妇COVID-19进展的生物标志物.
- 专注于复合血液图参数和全身炎症/尖端标志物.
- 评估血小板与淋巴细胞的比率 (PLR),血小板与中性粒细胞的比率 (PNR) 和中性粒细胞与淋巴细胞的比率 (NLR).
主要方法:
- 在单一中心进行前性病例对照研究.
- 包括怀孕妇女在他们的第二或第三个三个月的确诊COVID-19的妇女.
- 将COVID-19患者 (n=45) 与对照组 (n=43) 的COVID-19阴性患者进行比较.
- 评估的C-反应蛋白 (CRP),IL-6,IL-10,CD26和B7H4水平. 这些都是值.
主要成果:
- 血小板与中性粒细胞的比率 (PNR),血小板与淋巴细胞的比率 (PLR) 和C反应蛋白 (CRP) 在COVID-19患者中显著更高.
- 两组之间IL-6,IL-10,CD26或B7H4水平没有显著差异.
- 患者和对照组之间的人口和产科特征相似.
结论:
- 细胞C反应蛋白 (CRP),血小板与淋巴细胞比率 (PLR) 和血小板与中性粒细胞比率 (PNR) 显示出预测孕妇COVID-19病程的潜力.
- 需要进一步的综合性研究来验证这些炎症标志物.
- 额外的研究应该探索其他潜在的炎症标记在怀孕期间COVID-19.
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