肠道微生物代谢与循环非高密度脂蛋白胆固醇的变化有关
Shiyi Zhou1, Ludi Liu2, Bingqi Ye2
1Guangdong Provincial Key Laboratory of Food, Nutrition and Health, PR China; Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, PR China.
EBioMedicine
|May 10, 2024
概括
肠道微生物影响非高密度脂蛋白胆固醇 (非HDL-c) 的水平. 特定的细菌及其代谢功能,特别是三碳酸循环,对非HDL-c产生因果影响,提供了新的治疗点.
科学领域:
- 微生物组研究的研究.
- 代谢途径 代谢途径
- 心血管疾病风险因素 心血管疾病风险因素
背景情况:
- 非高密度脂蛋白胆固醇 (非HDL-c) 是心血管疾病的重要危险因素,也是降脂疗法的关键标.
- 人们越来越认识到肠道微生物群在宿主新陈代谢中的作用,但其对非HDL-c变异的直接因果影响仍然不完全理解.
研究的目的:
- 研究肠道微生物组成,代谢功能和非HDL-c水平之间的因果关系.
- 确定影响非HDL-c.的特定微生物物种和代谢途径.
- 探索将肠道微生物代谢与循环的非HDL-c联系起来的分子机制.
主要方法:
- 便元基因组学用于评估微生物物种和代谢能力.
- 包括斯皮尔曼相关性,LASSO和调整为心血管风险因素的线性回归在内的统计分析.
- 用血代谢学进行整合性分析,以确定连接分子.
- 双向门德尔随机化以建立因果关系.
主要成果:
- 特定的肠道细菌,如减少的Eubacterium rectale和增加的Clostridium sp CAG_299,与高的非HDL-c有因果关系.
- 十六种微生物代谢能力与非HDL-c独立相关,三碳酸 (TCA) 循环显示出最强的关联.
- 由于抑制了微生物减少TCA循环活性,降低了3-英多利酸和N-甲基三胺的水平,被确定为增加非HDL-c的关键调解者.
结论:
- 肠道微生物群对非HDL-c水平产生因果关系.
- 发现了非HDL-c与微生物代谢,特别是TCA循环之间的新联系.
- 修改微生物群的干预措施为调节非HDL-c和降低心血管风险提供了潜在的策略.
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