马拉暴露可能会增加美国成年人不孕症风险:来自2015-2016年NHANES研究的结果
Samantha R Streich1, Thomas A Beltran2, Bruce D Pier1
1Department of Obstetrics and Gynecology, Womack Army Medical Center, 2817 Rock Merritt Avenue, Fort Liberty, NC 28310, USA.
概括
马拉农药暴露与女性生殖健康问题有关. 这项研究发现,在遇到生育挑战的妇女中,马拉二酸水平较高,这突显了这种常见的有机酸农药的潜在风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生殖科学 生殖科学
背景情况:
- 像马拉一样的有机酸盐农药在全球广泛使用.
- 关于非持久性有机农药 (如马拉) 的慢性暴露影响的数据有限,尽管已知其具有内分泌干扰性质.
研究的目的:
- 评估美国居民对马拉的暴露水平.
- 研究马拉暴露对女性生育能力的潜在影响.
主要方法:
- 来自2015-2016年国家健康和营养检查调查 (NHANES) 的基于人口的数据的回顾性分析.
- 在1703名成年参与者中测量了尿液中马拉二酸度,加权以代表超过2.31亿个人.
- 一般线性模型检查了在绝经前妇女中马拉暴露和生殖健康指标之间的关联.
主要成果:
- 在16.1%的参与者中发现了可检测的马拉二酸度.
- 更高的度与报告因怀孕困难而去看医生的妇女有显著关联 (P < 0.001).
- 高水平也与妇女积极尝试怀孕至少一年 (P < 0.001) 相关.
结论:
- 马拉暴露与女性生殖健康挑战的病史有关.
- 研究结果表明,马拉暴露与难以怀孕之间存在潜在联系.
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