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在与类风湿性关节炎相关的间歇性肺病中,介质素-22的表达和诊断值

Quanquan Fang¹, Jingzhi Xie¹, Juan Zong¹

¹Department of Rheumatology and Immunology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221005, Jiangsu Province, China.

International immunopharmacology

|May 10, 2024

概括

与类风湿性关节炎相关的间歇性肺病 (RA-ILD) 患者的介质素-22 (IL-22) 水平较低,与疾病严重程度相关. IL-22,结合其他因素,显示出作为RA-ILD的生物标志物的潜力.

科学领域:

免疫学免疫学免疫学
肺部病理学肺部病理学
类风湿病学类风湿病学

背景情况:

风湿性关节炎相关的间歇性肺病 (RA-ILD) 的死亡率很高,需要早期检测生物标志物.
介质素-22 (IL-22) 在肺纤维化模型中显示出保护作用.

研究的目的:

在RA-ILD患者中评估IL-22表达.
为了验证IL-22在人类环境中的保护作用.
为了探索IL-22对RA-ILD的诊断价值.

主要方法:

用ELISA测量66名RA患者的IL-22水平 (33人患有ILD,33人没有ILD) 和14名健康对照.
使用后勤回归和ROC分析来确定预测因素并评估诊断价值.
开发了一种预测性名图,并使用30倍交叉验证进行验证.

主要成果:

与RA-无ILD组相比,RA-ILD组的IL-22水平明显较低.
较低的IL-22水平与RA-ILD严重程度相反相关.
IL-22,年龄,吸烟史,MCV-Ab和MCHC被确定为RA-ILD的独立预测因素.
结合了这些因素的组合模型,AUC达到0.97,交叉验证的AUC平均值为0.886.

结论:

在RA-ILD病原发生过程中,IL-22的表达失调.
IL-22有可能成为RA-ILD发生和进展的生物标志物.
包括IL-22在内的多因素模型为RA-ILD提供了更好的诊断准确性.

关键词:

介质素 22 介质素 22 类风湿性关节炎类风湿性关节炎类风湿性关节炎类风湿性关节炎相关的间歇性肺病.

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