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丝虫对氧化石墨烯暴露的生理和转录基因反应

Youchao Xin¹, Jiawen Liang¹, Chunjiu Ren¹

¹College of Forestry, Shandong Agricultural University, Tai'an 271018, China.

Ecotoxicology and environmental safety

|May 10, 2024

概括

石墨烯氧化物 (GO) 通过影响活性氧物种的排毒,对丝虫的生长,繁殖和发育产生负面影响. 核糖体生物发生-代谢信号网络参与了这些反应.

科学领域:

环境毒理学环境毒理学
纳米材料安全性评估
昆虫生理学昆虫生理学

背景情况:

像氧化石墨烯 (GO) 这样的纳米材料越来越多地被使用,需要评估它们对非目标生物的影响.
丝虫是研究昆虫对环境污染物的反应的有价值的模型,因为它们的经济重要性.

研究的目的:

综合调查石墨烯氧化物 (GO) 暴露对丝虫的生理和分子影响.
阐明基因组诱导昆虫毒性背后的机制.

主要方法:

丝虫暴露于不同度的GO.
评估了包括幼虫生长,化率和生殖发育在内的生理参数.
进行了转录组分析,以确定差异表达的基因.
测量了活性氧物种 (ROS) 水平和催化酶活性.

主要成果:

在丝虫中肠和丝腺中积累的GO.
高度的GO抑制了幼虫的生长,降低了化率,并影响了生殖发育.
对GO的暴露增加了ROS水平和改变了catalase活性,表明氧化应激.
转录组分析揭示了与代谢和核糖体生物发生相关的基因的差异表达.

结论:

石墨烯氧化物对丝虫构成重大毒理风险,影响多个生命阶段.
转基因诱导的毒性与氧化应激和关键细胞过程的破坏有关.
提出了一个新的Ribosome biogenesis-Metabolic信号网络,以调解丝虫对GO暴露的反应.

关键词:

石墨烯氧化物石墨烯氧化物代谢过程中的代谢.丝虫是一种丝虫.转录组转录组就是一个转录组.

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