在淡水环境中评估加多的致性风险:对环境健康的影响
Giulia Cesarini1, Federica Spani2, Raoul Patricelli3
1Department of Sciences, University of Roma Tre, Viale G. Marconi 446, Rome 00146, Italy; National Research Council-Water Research Institute (CNR-IRSA), Corso Tonolli 50, Verbania, Pallanza 28922, Italy.
Ecotoxicology and environmental safety
|May 10, 2024
概括
暴露于加多 (Gd) 在实验室环境中对Hydra vulgaris构成中度致风险. 环境Gd水平较低,排除了与意大利河流中观察到的风险的直接联系.
科学领域:
- 环境毒理学环境毒理学
- 发展生物学 发展生物学
- 生态毒理学 生态毒理学
背景情况:
- 加多 (Gd) 是一种稀土元素,由于MRI对比剂等医疗应用,环境中的存在越来越大.
- 污水处理系统往往无法去除Gd,导致其在水生生态系统中积累.
- 暴露于Gd的环境和生物风险,特别是其致病性潜力,需要进行彻底的调查.
研究的目的:
- 评估加多基酸盐对淡水鱼Hydra vulgaris的致病风险.
- 为了评估来自意大利河流的环境样本中的Gd度和原性风险.
- 确定Gd暴露与水生环境中观察到的原性影响之间的关系.
主要方法:
- 实验室实验使Hydra vulgaris暴露在不同度的加多胺和Omniscan®中.
- 用原性风险指数 (TRI) 和Hydra再生试验来评估原性.
- 来自提伯河,阿尔莫内河和萨科河的环境样本使用ICP-MS对Gd进行了分析,并评估了原性风险.
主要成果:
- 实验室暴露在100μg/l以上度的加多胺和Omniscan®中,表明有中度的原性风险 (III类TRI).
- 环境样本显示低Gd度 (≤0.1μg/l),在废水排放点附近局部增加.
- 环境样本中的原性风险差异很大 (I至IV类TRI),但低Gd水平排除了与观察到的影响的直接因果关系.
结论:
- 在实验室条件下,加多结合物对水生生物如Hydra vulgaris具有中度的致风险.
- 虽然Gd存在于意大利的河流中,但其度通常很低,因此它不太可能成为观察到的环境致病风险的主要原因.
- 需要进一步的研究来了解Gd对环境的影响的全部范围以及与其他污染物的潜在协同效应.
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