工程抗原呈现细胞用于自身免疫的免疫疗法
Clinton T Smith1, Zhenyu Wang1, Jamal S Lewis2
1J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Advanced drug delivery reviews
|May 10, 2024
概括
新疗法旨在针对自身免疫性疾病的抗原呈现细胞,提供比当前免疫抑制剂更精确的方法. 这可能会导致更好的治疗结果和更少的患者副作用.
科学领域:
- 免疫学 免疫学 免疫学
- 这是一种自身免疫力.
- 治疗方法 治疗方法
背景情况:
- 自身免疫性疾病影响全球许多人,其特点是免疫系统攻击宿主组织.
- 目前的治疗方法,免疫抑制剂,带有毒性和增加感染易感性等风险.
- 针对性免疫调节疗法的急需.
研究的目的:
- 审查针对自身免疫性疾病治疗中针对抗原呈现细胞 (APC) 的新兴策略.
- 探索APC向疗法如何改善现有的免疫抑制治疗方法.
- 突出发展更有效和更具体的免疫调节方法的进展.
主要方法:
- 审查目前的APC准策略的研究和开发.
- 对针对特定抗原呈现而设计的免疫调节疗法的分析.
- 检查自身免疫性疾病管理的临床前和临床方法.
主要成果:
- 确定各种方法,将免疫调节剂导向APC.
- 通过在源处调节免疫反应,增强治疗疗效的潜力.
- 与广泛的免疫抑制相比,减少了全身毒性.
结论:
- 向抗原呈现细胞是自身免疫性疾病治疗中的一个有希望的前沿.
- 这些新的方法可能会提供更好的安全性和有效性.
- 进一步开发对于将这些策略转化为临床实践至关重要.
相关概念视频
Antigen Presenting Cells
1.8K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
1.8K
Tumor Immunotherapy
518
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
518
Antigens Involved in Adaptive Immunity
486
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
486
Cell-mediated Immune Responses
68.2K
Overview
68.2K
Antigen Processing Pathways
1.0K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
1.0K
T Cell Activation and Clonal Selection
709
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
709


