雷姆睡眠中断对情感处理的影响:人类和动物实验研究的系统审查
Anu-Katriina Pesonen1, Maija-Kreetta Koskinen1, Neea Vuorenhela1
1SleepWell Research Program and Department of Psychology and Logopedics Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00014, Finland.
Neuroscience and biobehavioral reviews
|May 10, 2024
概括
动物和人类的快速眼动睡眠剥夺 (REMSD) 影响情绪处理,导致行为变化和改变记忆巩固. 慢性REMS抑制效应在很大程度上是未知的.
科学领域:
- 神经科学是一个神经科学.
- 睡眠科学 睡眠科学
- 行为科学 行为科学
背景情况:
- 快速眼动睡眠 (REMS) 在情绪处理中起着至关重要的作用.
- 实验性REMS剥夺 (REMSD) 是研究其影响的常见方法.
- 现有的研究表明,方法和结果各不相同.
研究的目的:
- 系统地审查实验REMS剥夺的结果.
- 为了比较动物模型和人类研究中的发现.
- 确定有关慢性REMS抑制的知识差距.
主要方法:
- 实验性REMS剥夺研究的系统审查.
- 在动物模型和人类研究中分析方法.
- 急性和慢性剥夺效应的比较.
主要成果:
- 动物模型:REMSD与侵略性,疼痛敏感性增加,性行为减少和恐惧记忆巩固受损有关.
- 动物模型:发育REMSD导致持久的情感行为变化.
- 人类研究:REMSD与增加疼痛敏感性和增强情绪记忆巩固有关.
结论:
- 雷姆斯德显著影响动物和人类的情绪处理和行为.
- 在REMSD研究中存在方法的变化.
- 慢性REMS抑制的长期影响,特别是SSRI等药理干预措施,需要进一步研究.
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