经过创伤后应激障碍的退伍军人进行胺增强的长期暴露治疗:一个随机对照试验协议
Paulo R Shiroma1, Paul Thuras1, Melissa A Polusny2
1Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, MN, United States of America; Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, United States of America.
Contemporary clinical trials
|May 10, 2024
概括
这项研究将调查胺与长期暴露 (PE) 疗法相结合是否改善退伍军人的PTSD治疗结果. 这项研究旨在确定胺的含量.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 目前的PTSD治疗指南建议以创伤为重点的疗法,如长期暴露 (PE).
- 然而,在30-50%的军人和退伍军人患者中,仅使用PE并不能显著改善症状.
- 胺,一种NMDA受体对手,在临床前研究中显示有潜力增强恐惧灭绝学习.
研究的目的:
- 为了比较胺与PE结合的胺与PE的安慰剂辅助剂,用于治疗退伍军人中PTSD.
- 评估胺增强PE治疗的疗效和安全性.
主要方法:
- 一个单场随机对照试验 (RCT) 涉及100名患有PTSD的退伍军人.
- 参与者将在PE课程开始前,在3周内接受胺或美达胺 (活性安慰剂) 输注.
- 结果将在3个月的随访期内进行评估,主要分析80名参与者,达到主要结果.
主要成果:
- 主要结果测量数据尚未提供,因为这是一个拟议的研究.
- 二次结果包括抑郁和焦虑得分,安全性,耐受性和认知表现.
结论:
- 这项研究旨在为PTSD中胺增强PE治疗提供科学依据.
- 这些发现可以完善治疗方法,阐明潜在机制,并确定最受益的特定患者子组.
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