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Updated: Apr 10, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
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毒理学评估和对糖单烯酸盐的初步暴露评估

Jin Fang1, Yongquan Feng1, Haibo Liu1

  • 1NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (2019RU014), China National Center for Food Safety Risk Assessment, Beijing, 100021, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
|May 10, 2024
PubMed
概括

在测试中,甘单酸盐 (GMC) 没有显示出基因毒性. 一项为期90天的研究确定了每天可接受摄入量 (ADI) 为每天40.8毫克/千克体重,证实了中国消费者目前水平的安全性.

关键词:
可接受的每日摄入量饮食暴露评估 饮食暴露评估基因毒性 基因毒性糖单烯酸盐是一种糖单烯酸.风险评估 风险评估 风险评估亚慢性毒性 亚慢性毒性

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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